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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0f107e7cb3e392980bce1fa8988d377c0148bf2380ec42da78940223890333df' 
  AND token = 'Z2CdlE/fAK2gyg7v5Le18rFzqdqeHnr6lFZaWsYYNYU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}