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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1c4a71d82e13f0eacb82bcd439dcf8bda8f3bc3ad60ef4e02c22c0884e50357f' 
  AND token = 'XDokePBo0UEmRPv+6M8GBNX0ePFQ/EUE2E3fiWrBo5g=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}