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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6821ec362540f3f3d0dc690a355b0f314aabb5546bd7e3b664a41e433a10e54e' 
  AND token = 'hG0OnbKxdM9zvZlUzt9dDQzE3+rN8kIiD3x3JeH9uaY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}