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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a443d78335846ecc1b549f61ac8f9f360e6537d0fada5b51c9c45dcb029c0e8e' 
  AND token = 'wc7tJrlVKbWUevre/ng7EkYAwdRN09YiFuyXvPxLuog=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}