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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4a2ede9263e3fd85d72bbebe494b71506f4141b40b78f6a9eb10662d2edeece5' 
  AND token = 'NEpFMWyaIZCJ+a3ZAF0MWBtz8Cj0s1+WmfB7Dool5fE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}