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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1978aff4ceda302ab7c7bf7f3d92917f2e6ae8ce76009ac30c063047ad7e1348' 
  AND token = 'LTWFRVpJv+1X7b4NPPCDF1FtCqhtAjtIME6ZkZ4IqME=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}