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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '307f1c861f768cb26feb6e92c73b62f4547fc4d3440828eb3aef2ad4a2e18215' 
  AND token = 'nO4mFS4xBOEC4f1ZbHz7s5FDv7uLeVHpiPg3Fnbazw0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}