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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '499153af928222b2b4af87b9aaab2f57b4ab4f70ca45ba58e324bb3702cac585' 
  AND token = 'bC3/NZcy8oKQHc06KuuZ8DOBA6ll7LsSQGMmQcw25sk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}