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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b722645c87e2629b55a423e8e49ae5d3e01233eb30dc147389899bade6f5fde7' 
  AND token = 'IDymCrcBDEi/H6bl1kAvtIgzXcjjkLMOgxT8FgaLhxo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}