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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8c888ae255f8f58ca1149e97810f0eef09083b5bb2c1dedc36aedd244948446b' 
  AND token = 'cVGUfCO0vb7Auy9ANknk+B/oKrWO5uwbo9Su9Qxr/oQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}