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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8dd0e71223bd3648b86a9a212a109ed367847c0274e4b7b7f2172867dd08ed5f' 
  AND token = 'EmXv3CuFSAEyPR1RGwyC4yBTCyCJWsAJHXprBOpMuUI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}