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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a221bed46b58fb852b302fccf4424a17c7bace3a4503081f4bd9d11dea4bf525' 
  AND token = 'RoPN/HIiTkPanrkVxm4UDEc4Dy7MD4GNmFFPxxX3JH4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}