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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '71269a42c6c7c2fc33143b141c507ceabe9dab428a36a56b0701bc7a25b1efdf' 
  AND token = 'lTyGVIDeqY6wvpfWQhMdYbyQePWz9RpYymkkbfjZyEE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}