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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '43c786d1124a69dc625ba03525c2123a9f653a01b562e618cae339446213a6dc' 
  AND token = 'nll4LcWdxdnZIia39hbRygwrArFlhpJNBeuR/yu499Y=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}