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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2157a80d737b4e237f6dc7c8e66b29e510383043bfae6b78616f08ec7afbaf08' 
  AND token = 'cIyaqgSbbNOJ7YLk73nhfAE8+qb3hX5hRi8GoycD1yE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}