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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '501cc565c984339be6b18628216a9cb64d0a3d157c550fef9c0198f7175d8d39' 
  AND token = 'JT+C+RMBXv+iaTXlb6P46rl7sTZWGF3OdbOrxvfnhP0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00034

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}