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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '00ff1d6cb53c9be4839249a802fdf4125f9e80cdd22050f5e1a92efc24f03175' 
  AND token = 'UoiWt0O2DkeTcleI+82e5MyWD+Dd77GYaZwBFCaDGEM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}