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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '243588c0dc16727e2f9a4b2a55db0035edfc306b0925ffa020e2a324d444e213' 
  AND token = '6NjeIdNaN8vGBLL0O5SmXeSkg/KvhJx8LBOW9K+4XUs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}