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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2176e63959b20f099e447ad8d7bcf15477b392f2c482d0f8ad59eaa939a0723d' 
  AND token = 'zDZGPy8qQo1yqbE4NkI+iEt7uH0Izov6xwM0Y/jaPxE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}