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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a24edcf09943b6bc46867957120b8dfbc5fde1bc8c749a47672866bab0c9c6f1' 
  AND token = 'OFxx8OS1NQvhAVWTC81Sd+wxifkFhQj17FoIW6ksMWg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}