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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c643275691c0e517eefffb2a142665bb14e46d47006b7bcf052bc127a65d459c' 
  AND token = 'TK/2YG6WPC/VA7zOBsF0pmYGbj2Qo7uFKbnMqc/+Z3Y=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}