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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8378331e2c5a4602132df6a526809a37d8ee211ce8c3c69876c576bcf0fcb2e2' 
  AND token = 'YD7qPn6cTCUV2zyzhmfyMOAQgOeyWWtzbnaCnNL83o0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00016

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}