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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd166e4b845500e537f95f37877f0f150b53e3f7c073086e3715761d7bb56715e' 
  AND token = 'iCFZM5tX3OgAI9h+AQPTkSXU13rzfBf+rWIc0xFrXe8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}