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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd2ce3389f49d4e45c97f40ecc246f6856b165a0dd298eef3cacf662a7c9a63e7' 
  AND token = 'ysZYvr20zFyyQlhzOHRBlXHiHTCkTmrqXopUHroZ5nQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}