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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '191378b85159b6a81a5c30041cdc6e4de278ff9400039c7fec485343239ab496' 
  AND token = '4BmhLIGA9b/Qa9ruJLzsuqvuvDa4Wib0Fb1yZxcPZdA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}