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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '12c5b0eac951e0b5c4f655c9527c025a102f73db398e3b0b22e09bf4e6a2abee' 
  AND token = 'cvigyJ9k+MUWGTOVFWyB9qrcUERYiR/y/UKGP3JEVAw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}