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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '53f7d5e37b52a4235c5418a081e7299188e209e5ba78e59fb0bc696aa087ef1b' 
  AND token = 'lF6EnRBxXL2QvqqIyVwkHixhSD2OfI7hYikDe9rJ6cw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}