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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '59642c921465e39de009ec7568843b65ab34486951d8618d310265d7b36b36a1' 
  AND token = 'ndOz2T2IODNEbE5F2SuxIxRyZDwc61ZhokN4hahb3SE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}