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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3c7b0d43c3f21503f338134583898d85d7a6bd02aa18f0b6930022a7fd90ad7b' 
  AND token = 'jJ2v2zLKkegEaUWr1X3VNbre5q+qQfLjTdxQfRuYuuM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}