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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '38175107c43c092f538e1fbcc7b464b568caf80809b9ada4dd3ff244d1bd05c0' 
  AND token = 'ykXQ3qNQp1V7Pdb1AjFRFJCfYDSMFPfJIQqkhHPYH6o=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}