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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '280a57b3ea0e354320e1988125da8c662e32b6489ab2c369f1963be53eae26c4' 
  AND token = 'DXuTZam4sdFc+/o0vdEpXXfs+Zm7Ifpr+VsbbgsopG0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}