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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '49c13741e9bb08e6b0a7f780daca59c0e80babd02ccd2fd8c4b33e6cae668f45' 
  AND token = 'eNA/3Mr7NxYDKi0MQSF5iB6ZXQtfpub6u15poIQXIZs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}