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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '550243a128cadd419e3bbc82398ab6eeb36d8c8e6f08f900e752ce1b62965d7b' 
  AND token = 'yyd0xvvD1U3Ng/FLTNdyLTjR+oWmJH3uTjtIvZdTRs0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00015

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}