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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '45a6a93219d314f3aa4e6c110e01b51392bc96d9e50bbc7490cbe963c8199133' 
  AND token = 'pR7mL+5SahXxdvYvP3khNtWccG9nxf0g2u07zlG3lg8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00015

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}