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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6ade38ac460922d4542c8849f069645c76b4fac62c3c29a87c4609c004939adb' 
  AND token = 'xDZxq4wcb6u1j21PqD/rFdyeQ/UPFeaXcT+A3dH2Njo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}