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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8ef26f272940933cac1b2ba8bea782b18819892b1f3498f335c55c2b16746021' 
  AND token = 'mHz/hMP397faR+xyn+2sv8rK5b2iorMi6H73NPw8bMM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}