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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c0ff363326f78c602a009736ae6902a85dace2d40a1a46f7ce08963ea1b12c44' 
  AND token = 'jYlWIVpF3gk1tixDGHCN7M5JMXX18nIALLKVHDsXEig=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}