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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4df09b3d4e552beba7aaf88411623999a6e3d3bb7a06d8c56569fd4fc6bf227c' 
  AND token = 'iXpslJ8isgJQGy0jydol1SXCoyJ1ToaCAS+YjSUQ53w=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}