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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '42c8287fa67f700817db09bfdc04c25d8a96bc942995b365221420356c839224' 
  AND token = 'BreXwVw8bdf7a1EOo2xl/abp8NFjgF3cKebJ34jEnas=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}