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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '052d121ee7cb3256f90b7fc9c20e7742fb73d8bc6dec47c95c12dad73f655646' 
  AND token = 'eHmxl4rnY/yCaFITf3P2zBf1/qa8ZNts4zenWDbvnA4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}