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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3ac4edc91815e61ff15d330740aeb49698d8fb68e6a5a8aef6ca035d2c1e504f' 
  AND token = 'Gc5jwk6DXyDoR7YDX3+1xYwNFkKzqLm7ctut/RCS5V4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}