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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '44551ab8bd8f2e10dc10337b135962043856f085e9c21e05f8c37488d54dd8f1' 
  AND token = 'E/4UMGy+XFsn9JJp3N0qmK0awDYZxrimEgxpWQAA7Nw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}