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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '7b0112023f1be1dd0b2d4d33014e54a6a2f5288be4ac963cf02ec44845a7b7c4' 
  AND token = 'oHu0xgNuZqHrurh4bAVp3awGmIeA5+q2fMPk0zbvYV8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}