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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '42ae8d352448728c9cc5c21aabb2bca42e29367a4d9928cc39b3e7731b09c65e' 
  AND token = 'wM4JjjF2D08WeFybRzVukco8RfGBwtlktfHDYJWFq4k=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}