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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c9241284728a5f2e102256e0a015490db75b2e36f145b49ab55a3b7d26eff541' 
  AND token = 'ffZ0VtSPZZZ0XpKQjE9FQO/h8MBmfY5gg6/zbN0VIlo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}