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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '273ad4dd29c682a01f8d89a4eceb40e1d39722c1bde1b72968428b1d1e4d217c' 
  AND token = 'fh/+IXr/nVJFus0zj3BrIOqlBrmkluRDQz1fTAxnD7Y=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}