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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2ad4de7690ada7d3a3d3543ebba6e929ae5d9b2a919e2cfb968287c23f4c1860' 
  AND token = 'l5cxGX51XD1kbIHxWa2C4WLFMN+sXYtVHOj5ybpxYFE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}