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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ad6052827e909fc06c99fe71bdcaf800ddab4edc489269d75ce64b4eb781b509' 
  AND token = '+IbwfcE0DpEnMGl/dDS/xYZCx6X8iA9pR3w8vvVwgEs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}