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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2b41e529ba7741245f5b865d5d88f63e4fe572edaf29f8b65cb3860e584e4f5e' 
  AND token = 'uPs2mmmPddAFYDxlBrIGDNchQQVe045r2kAdOYS2eOg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}