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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c5ebd6efd4e94d89208af6f615397aa3468d34a6e5a961205ce788d46e95c30f' 
  AND token = 'maz0R5S17tE+uXElEm+PFXYut8n4WjDMJ4PNTw1x8hU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}